李焱 副研究員 副研究員，博士 E-mail: liyan927818@163.com

　　2008年畢業于濟寧醫學院，獲臨床醫學學士學位。2011年畢業于上海交通大學醫學院腫瘤研究所，獲腫瘤學碩士學位。2014年畢業于上海交通大學醫學院腫瘤研究所，獲生物化學與分子生物學博士學位。 2014年7月至今就職于復旦大學附屬腫瘤醫院/腫瘤研究所。主持項目包括國家自然科學基金青年項目一項，國家自然科學基金面上項目一項，并作為課題骨干參與國家自然科學基金重點項目及面上項目多項。主要研究成果發表于Cell Research，Cancer Letters, Science Signaling, Cell Death and Disease, Methods in Molecular Biology等專業雜志上 。 

研究方向：

　　1、非編碼RNA (circRNA , miRNA, lncRNA) 在消化道腫瘤中的鑒定、功能及分子機制研究。
　　2、腫瘤細胞外泌體中核酸、蛋白的鑒定、功能及其臨床意義。

代表性論著：

1. Li Yan^#, Chen Bing, Huang Shenglin^*. Identification of circRNAs for miRNA Targets by Argonaute2 RNA Immunoprecipitation and Luciferase Screening Assays. Methods Mol Biol, 2018; 1724:209-218.
2. Jie Chen^#, Yan Li^#, Qiupeng Zheng, Chunyang Bao, Jian He, Bing Chen, Dongbin Lyu, Biqiang Zheng, Yu Xu, Ziwen Long, Ye Zhou, Huiyan Zhu, Yanong Wang, Xianghuo He, Yingqiang Shi^*, Shenglin Huang^*. Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. Cancer Letters, 2017 Mar 1; 388:208-219.
3. Zhou Zhenhua^#, Li Yan^#, Wang Xudong^#, Hu Jingjing, Kuang Muyu,Wang Zhiwei, Li Song, Xu Weidong, Xiao Jianru^*. ALCAM(+) stromal cells:role in giant cell tumor of bone progression. Cell Death & Disease, 2018 Feb 20; 9(3):299.
4. Shengli Li, Yuchen Li, Bing Chen, Jingjing Zhao, Shulin Yu, Yan Tang, Qiupeng Zheng, Yan Li, Peng Wang, Xianghuo He, Shenglin Huang^*. exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Research, 2018 Jan 4; 46(D1):D106-D112.
5. Zhou Zhenhua^# , Li Yan^#, Jia Qi^# ,Wang Zhiwei, Wang Xudong, Hu Jingjing, Xiao Jianru^*. Heat shock transcription factor 1 promotes the proliferation, migration and invasion of osteosarcoma cells. Cell Prolif, 2017 Aug; 50(4):e12346.   
6. Zhenhua Zhou^#, Yan Li^#, Huiqing Wang^#, Xudong Wang , Jianru Xiao^*. Biological Features of a Renal Cell Carcinoma Cell Line Derived from Spinal Metastasis. DNA Cell Biol, 2017 Feb; 36(2):168-176.
7. Qiupeng Zheng^#, Chunyang Bao^#, Weijie Guo, Shuyi Li, Jie Chen, Bin Chen,Yanting Luo, Dongbin Lyu, Yan Li, Guohai Shi, Linhui Liang, Jianren Gu, Xianghuo He^*, Shenglin Huang^*. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nature Communications, 2016 Apr 6; 7:11215.
8. Yan Li^#, Qiupeng Zheng^#, Chunyang Bao, Shuyi Li, Weijie Guo, Jiang Zhao, Di Chen, Jianren Gu, Xianghuo He^*, Shenglin Huang^*. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Research, 2015 Aug; 25(8):981-4.
9. Chunyang Bao^#, Yan Li^#, Lin Huan, Yuannv Zhang, Fangyu Zhao, Qifeng Wang, Linhui Liang, Jie Ding, Li Liu, Taoyang Chen, Jinjun Li, Ming Yao, Shenglin Huang^*, Xianghuo He^*. NF-kB signaling relieves negative regulation by miR-194 in hepatocellular carcinoma by suppressing the transcription factor HNF-1a. Science Signaling, 2015 Jul 28; 8(387):ra75.  
10. Li Y^#, Xu D^#, Bao C^#, Zhang Y, Chen D, Zhao F, Ding J, Liang L, Wang Q, Liu L, Li J, Yao M, Huang S^*, He X^*. MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma. Oncotarget, 2015 Feb 10; 6(4):2421-333.