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      副研究員

      閆明霞 副研究員
      副研究員,博士
      E-mail: mingxia_yan@126.com
       

            2000年畢業于佳木斯大學臨床醫學專業獲得臨床學士學位,2005年畢業于復旦大學動物學專業獲得理學碩士學位,2011年畢業于上海交通大學腫瘤學專業獲得腫瘤學博士學位。2005年7月-2018年5月就職于上海市腫瘤研究所,2018年6月起就職于復旦大學附屬腫瘤醫院,擔任腫瘤研究所實驗動物平臺主管。目前任上海市實驗動物學會理事,上海市實驗動物學會資源與設施專業委員會副主任委員,擔任《實驗動物與比較醫學》編委。工作以來主要從事腫瘤高轉移動物模型篩選及建立、腫瘤轉移相關分子機制等研究工作。以第一作者、通訊作者發表論文10余篇,參與發表論文20余篇;以第一責任人申請國家自然科學基金2項、上海市科委“創新行動計劃”等課題8項,總經費約300萬元,作為骨干參與國家“973”、國家十二五科技重大公關等課題研究;以第一發明人申請國家發明專利4項,參與申請5項,其中2項獲得專利授權。參編專業書籍2本,獲得上海醫學科技獎三等獎1項。


      研究領域:

        腫瘤轉移的分子機制研究及抗腫瘤轉移的治療研究:
        1. 腫瘤轉移動物模型的篩選及建立
        2. 基于動物模型的抗腫瘤轉移治療研究
        3. 腫瘤轉移的分子機制研究


      代表性論著:

      1.  Li Jing#, Cheng Dongdong#, Zhu Miaoxin, Yu Huajian, Pan Zhen, Liu Lei, Geng Qin, Pan Hongyu, Yan Mingxia*, Yao Ming*.OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer. Theranostics, 2019; 9(1):179–195.

        metastasis of human non-small-cell lung cancer by downregulating the ERBB4/PIK3R3/mTOR/S6K2signaling pathway. Oncogene, 2015; 34:413-423.

      2. Chu D#, Li J#, Lin H, Zhang X, Pan H, Liu L, Yu T, Yan M*, Yao M*.Quantitative proteomic analysis of the miR-148a-associated mechanisms of metastasis in non-small cell lung cancer.Oncol Lett., 2018; 15(6):9941–9952.

      3. Hechun Lin#, Xiao Zhang#, Li Liao, Tao Yu, Jing Li, Hongyu Pan, Lei Liu, Hanwei Kong, Lei Sun, Mingxia Yan*, Ming Yao*. CPNE3 promotes migration and invasion in non-small cell lung cancer by interacting with RACK1 via FAK signaling activation. J Cancer., 2018; 9(22):4215–4222.

      4. Dandan Chu#, Jing Li#, Hechun Lin, Xiao Zhang, Hongyu Pan, Lei Liu, Tao Yu, Mingxia Yan*, Ming Yao*. Quantitative proteomic analysis of the miR-148a-associated mechanisms of metastasis in non-small cell lung cancer.OncolLett., 2018; 15(6):9941–9952.

      5. Yu T#, Zhao Y#, Hu Z, Li J, Chu D, Zhang J, Li Z, Chen B, Zhang X, Pan H, Li S, Lin H, Liu L, Yan M, He X*, Yao M*.MetaLnc9 Facilitates Lung Cancer Metastasis via a PGK1-Activated AKT/mTOR Pathway.Cancer Res., 2017; 77(21):5782-5794.

      6. Wei Deng#, Mingxia Yan#, Tao Yu, Haiyan G, Hechun Lin, JingLi, Ying Liu, Qin Geng, Miaoxin Zhu, Lei Liu, Xianghuo He*, Ming Yao*. Quantitative proteomic analysis of the metastasis-inhibitory mechanism of miR-193a-3pin non-small cell lung cancer.Cell PhysiolBiochem., 2015; 35:1677-1688.

      7. Cui YQ#, Geng Q, Yu T, Zhang FL, Lin HC, Li J, Zhu MX, Liu L, Yao M*, Yan MX*. Establishment of a highly metastatic model with a newly isolated lung adenocarcinoma cell line.Int JOncol., 2015; 47(3):927-940.

      8. Jing Li#, Tao Yu#, Jun Cao, Lei Liu, Ying Liu, Han-Wei Kong, Miao-Xin Zhu, He-Chun Lin, Dan-danChu, Ming Yao*, Ming-Xia Yan*.MicroRNA-148a Suppresses Invasion and Metastasis of Human Non-Small-Cell Lung Cancer. Cell PhysiolBiochem., 2015; 37:1847-1856.

      9. Mingxia Yan#, Hong Li, Miaoxin Zhu, Fangyu Zhao, Lixing Zhang, Taoyang Chen, Guoping Jiang, HaiyangXie, Ying Cui, Ming Yao, Jinjun Li*.GProtein-Coupled Receptor 87 (GPR87) promotes the growth and metastasis of CD133+ cancer stem-like cells in hepatocellular carcinoma. PLoS ONE, 2013; 8(4): e61056.

      10. Mingxia Yan#, Hong Li, Fangyu Zhao, Lixing Zhang, Chao Ge, Ming Yao, Jinjun Li*.Establishment of NOD/SCID mouse models of human hepatocellular carcinoma via subcutaneous transplantation of histologically intact tumor tissue. Chin J Cancer Res., 2013; 25(3): 289-298.

      11.  Tao Yu#, Jing Li, Mingxia Yan, Lei Liu, Hechun Lin, Fangyu Zhao, Lei Sun, Yu Zhang, Yongqi Cui, Fanglin Zhang, Jinjun Li, Xianghuo He, Ming Yao*. MicroRNA-193a-3p and -5p suppress the

       
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