復旦大學腫瘤研究所

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副研究員

侯海峰 副研究員

副研究員，博士

E-mail: houhf@fudan.edu.cn

　　2003年獲北京理工大學學士學位，2008年獲中國科學院高能物理研究所博士學位，2008年-2017年在中國科學院高能物理研究所工作，歷任助理研究員和副研究員，從事結構生物學研究。期間于2010-2011年前往美國西南醫學中心藥理系從事博士后研究。2017年7月任職于復旦大學附屬腫瘤醫院腫瘤研究所。主持和參加多項國家自然科學基金青年項目和面上項目，參加多項自然科學基金重點項目和973項目。研究成果發表于Nature, Cell Research, JMB, JBC等國際期刊。

研究領域：

綜合利用生物物理，生物化學的方法研究超大復合體的結構與功能。目前正在開展染色質結構調控和DNA損傷修復等方面蛋白質復合物的結構功能研究。希望揭示這些復雜生命過程的基本原理，并為靶向藥物研發提供結構基礎。

代表性論著：

Li Y, Guo Z, Jin L, Wang D, Gao Z, Su X, Hou H^*, Dong Y^*. Mechanism of the allosteric regulation of Streptococcus mutans 2'-deoxycytidylate deaminase. Acta Crystallogr D Struct Biol, 2016 Jul; 72(Pt 7):883-91.
Chen Z, Zhan LH, Hou HF, Gao ZQ, Xu JH, Dong C, Dong YH. Structural basis for the interaction of BamB with the POTRA3-4 domains of BamA. Acta Crystallogr D Struct Biol, 2016 Feb; 72(Pt 2):236-44.
Hu L, Lu J, Cheng J, Rao Q, Li Z, Hou H, Lou Z, Zhang L, Li W, Gong W, Liu M, Sun C, Yin X, Li J, Tan X, Wang P, Wang Y, Fang D, Cui Q, Yang P, He C, Jiang H, Luo C, Xu Y. Structural insight into substrate preference for TET-mediated oxidation. Nature, 2015 Nov 5; 527(7576):118-22.
Wang W, Hou H, Du Q, Zhang W, Liu G, Shtykova EV, Xu J, Liu P, Dong Y. Solution small angle X-ray scattering (SAXS) studies of RecQ from Deinococcus radiodurans and its complexes with junction DNA substrates. J Biol Chem, 2013 Nov8; 288 (45):32414-23.
Zhang Y, Gao Z, Guo Z, Zhang H, Zhang Z, Luo M, Hou H, Huang A, Dong Y, Wang D. The crystal structure of human protein α1M reveals a chromophore-binding site and two putative protein-protein interfaces. Biochem Biophys Res Commun, 2013 Sep 27; 439 (3):346-50.
Liu S, Zhang W, Gao Z, Ming Q, Hou H, Lan W, Wu H, Cao C, Dong Y. NMR structure of the N-terminal-most HRDC1 domain of RecQ helicase from Deinococcus radiodurans. FEBS Lett, 2013 Aug 19; 587(16):2635-42.
Dong C, Yang X, Hou HF, Shen YQ, Dong YH. Structure of Escherichia coli BamB and its interaction with POTRA domains of BamA. Acta Cryst D, 2012; 68:1134-9.
Dong C, Hou HF, Yang X, Shen YQ, Dong YH. Structure of Escherichia coli BamD and its functional implications in outer membrane protein assembly. Acta Cryst D, 2012; 68:95-101.
Zhang H, Gao ZQ, Hou HF, Xu JH, Li LF Su XD, Dong YH. High-resolution structure of a new crystal form of BamA POTRA4-5 from Escherichia Coli. Acta Cryst F, 2011; 67:734-738.
Li Y, Gao Z, Hou H, Li L, Zhang J, Yang H, Dong Y, Tan H. Crystal structure and site-directed mutagenesis of a nitroalkane oxidase from Streptomyces ansochromogenes. Biochem Biophys Res Commun, 2011; 405(3): 344-8.
Yang Y, Hu L, Wang P, Hou H, Lin Y, Liu Y, Li Z, Gong R, Feng X, Zhou L, Zhang W, Dong Y, Yang H, Lin H, Wang Y, Chen CD, Xu Y. Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Research, 2010 Aug; 20(8):886-98.
Zengqiang Gao, Haifeng Hou and Yuhui Dong. Chap7. Protein Crystallography for Metalloproteins, Nuclear Analytical Techniques for Metallomics and Metalloproteomics. Royal Society of Chemistry Press,2010; 212-235.
Haifeng Hou^# and Hongtao Yu. Structural insights into histone lysine demethylation. Current opinion in structural biology, 2010 Dec; 20(6):739-48.
C.-P. Liu, R. Xu, Z.-Q. Gao, J.-H. Xu, H.-F. Hou, L.-Q. Li, Z. She, L.-F. Li, X.-D. Su, P. Liu and Y.-H. Dong. Structure of orotate phosphoribosyltransferase from the caries pathogen Streptococcus mutans. Acta Cryst F, 2010; 66:498-502.
Hai-Feng Hou^#, Yu-He Liang, Lan-Fen Li, Xiao-Dong Su，and Yu-Hui Dong. Crystal Structures of Streptococcus mutans 2′-Deoxycytidylate Deaminase and Its Complex with Substrate Analog and Allosteric Regulator dCTP·Mg²⁺. Journal of Molecular Biology, 2008; 377:220-231.
GAO Zeng-Qiang, HOU Hai-Feng, LI Li-Qin, XU Rui, LIANG Yu-He, LI Lan-Fen, SU Xiao-Dong, DONG Yu-Hui. Protein Preparation, Crystallization and Preliminary X-ray Crystallographic Analysis of Smu.195c From Caries Pathogen Streptococcus mutans. Progress in Biochemistry and Biophysics, 2007; 34(2):203-206.
Z.-Q. Gao, H.-F. Hou, Y.-H. Liang, L.-F. Li, X.-D. Su & Y.-H. Dong. Protein Preparation, Crystallization and Preliminary X-Ray Crystallographic studies of Smu.1392c from Streptococcus mutans. Protein and Peptide Letters, 2006; 13:1051-1052.
HOU Hai-Feng^#, GAO Zeng-Qiang, XU Jian-Hua, XU Rui, LI Li-Qin, LI Lan-Fen, LIANG Yu-He, SU Xiao-Dong, LIU Peng, XIAN Ding-Chang, DONG Yu-Hui. Expression, Purification, Crystallization and Preliminary X-ray Studies of a Deoxycytidylate Deaminase From Streptococcus mutans. Progress in Biochemistry and Biophysics, 2006; 33(7):673-676.