復旦大學腫瘤研究所

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副研究員

王夢筠 副研究員

副研究員，博士

E-mail: wangmengyun1120@163.com

　　2006年獲得南京師范大學理學學士學位，2009年獲得上海交通大學生物化學與分子生物學碩士學位，2017年獲得復旦大學腫瘤學博士學位，2009年至今就職于復旦大學附屬腫瘤醫院腫瘤研究所，主要從事惡性腫瘤的分子流行病學研究，主持或參加多項國家自然科學基金青年項目和面上項目，已發表SCI論文50余篇，研究成果發表于Nature Genetics, Carcinogenesis, Scientific Reports, Pharmacogenetics and Genomics等國際雜志上。

研究領域：

　　主要從事惡性腫瘤的分子流行病學研究，系統研究遺傳變異與腫瘤發生、發展的關系，以及腫瘤病因學里的基因-環境交互作用。同時著重遺傳變異與患者預后的關系以及相關分子機制的研究，以期篩選出可應用于預測發病風險和臨床預后的分子標志物來指導腫瘤的預防和個體化治療。

代表性論著：

Wang M^#, Li Q^#, Gu C, Zhu Y, Yang Y, Wang J, Jin L, He J, Ye D^*, Wei Q^*. Polymorphisms in nucleotide excision repair genes and risk of primary prostate cancer in Chinese Han populations. Oncotarget, 2017; 8: 24362-71.
Wang MY, Jia M, He J, Zhou F, Qiu LX, Sun MH, Yang YJ, Wang JC, Jin L, Wang YN, Wei QY. MDM4 genetic variants and risk of gastric cancer in an Eastern Chinese population. Oncotarget, 2017; 8: 19547-55.
Wang MY^#, He J^#, Zhu ML, Teng XY, Li QX, Sun MH, Wang XF, Yang YJ, Wang JC, Jin L, Wang YN^*, Wei QY^*. A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population. Sci Rep, 2016; 6: 20008.
Wang MY^#, Li QX^#, He J, Qiu LX, Wang YN, Li J, Sun MH, Wang XF, Yang YJ, Wang JC, Jin L, Wei QY. Genetic variations in the mTOR gene contribute toward gastric adenocarcinoma susceptibility in an Eastern Chinese population. Pharmacogenet Genomics, 2015; 25: 521-30.
Wang MY, Zhu ML, He J, Shi TY, Li QX, Wang YN, Li J, Zhou XY, Sun MH, Wang XF, Yang YJ, Wang JC, Jin L, Wei QY. Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. PLoS One, 2013; 8: e74041.
Wang M, Zhang R, He J, Qiu L, Li J, Wang Y, Sun M, Yang Y, Wang J, Yang J, Qian J, Jin L, Ma H, Wei Q, Zhou X. Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. PLoS One, 2012; 7: e31932.
Zhang GM^#, Wang MY^#, Liu YN, Zhu Y, Wan FN, Wei QY^*, Ye DW^*. Functional variants in the low-density lipoprotein receptor gene are associated with clear cell renal cell carcinoma susceptibility. Carcinogenesis, 2017 Dec 7; 38(12):1241-1248.
Zhu J^#, Wang M^#, He J, Zhu M, Wang JC, Jin L, Wang XF, Yang YJ, Xiang JQ*, Wei Q*. Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population. J Cell Mol Med, 2016; 20: 666-77.
Zhu J^#, Wang M^#, Zhu M, He J, Wang JC, Jin L, Wang XF, Xiang JQ^*, Wei Q^*. Associations of PI3KR1 and mTOR polymorphisms with esophageal squamous cell carcinoma risk and gene-environment interactions in Eastern Chinese populations. Sci Rep, 2015; 5: 8250.
Wei Q^#, Yu D^#, Liu M^#, Wang M^#, Zhao M, Jia W, Ma H, Fang J, Xu W, Chen K, Xu Z, Wang J, Tian L, Yuan H, Chang J, Hu Z, Wei L, Huang Y, Han Y, Liu J, Han D, Shen H, Yang S, Zheng H, Ji Q, Li D, Tan W, Wu C, Lin D. Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. Nat Genet, 2014; 46: 1110-4.